John F. Engelhardt, Ph.D.
Director of the Center for Gene Therapy
Professor and Head, Department of Anatomy and Cell Biology
Link to the Engelhardt Lab web site


B.S., Iowa State University, Ames, IA (Biochemistry), 1985
Ph.D., Johns Hopkins University, Baltimore, MD (Human Genetics), 1990
Research Associate, University of Michigan, Ann Arbor, MI (HHMI), 1992
Research Associate, University of Michigan, Ann Arbor, MI (Internal Medicine), 1993

Research Focus:

Research in the Engelhardt laboratory focuses on the molecular basis of cystic fibrosis disease pathologies, and on the development of gene therapies for this disorder. Included are four major research areas include the study of: 1) lung molecular and cellular biology as it relates to the pathogenesis and treatment of cystic fibrosis (CF) lung disease, 2) the development of viral vector for gene therapy and gene editing, 3) pathogenesis cystic fibrosis related diabetes, and 4) the study of airway stem cell niches, the regulatory mechanisms that control stem cell proliferation and repair in the airway, and the development of cell-based therapies for CF using stem cells. 

Publications from PubMed